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| Principal Investigator |
Principal Investigator's Name: |
Patrick J. Brown |
E-mail: |
pb2410@columbia.edu
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Institution: |
College of Physicians and Surgeons, Columbia University |
Department: |
Division of Geriatric Psychiatry |
Country: |
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Proposed Analysis: |
Objective 1: To identify the neuropsychological and neuroimaging correlates to functional impairment (FAQ) in individuals with Mild Cognitive Impairment, and to compare them to Alzheimer???s disease patients and controls.
Objective 2: To identify the individual FAQ items that distinguish the three diagnostic groups, and that are associated with the degree of neuropsychological deficits in tests of memory, verbal fluency, and executive function.
This project will be undertaken by Drs. Brown and Devanand continuing a line of research based on previous findings on the functional impairment of patients with MCI conducted in the Division of Geriatric Psychiatry at Columbia University (Tabert et al., Functional deficits in patients with mild cognitive impairment: Prediction of AD. Neurology 2002; 758-764), and relates to a new article in press by Landau et al. (2009) in Neurobiology of Aging.
Baseline evaluation data from the ADNI database only will be analyzed for this paper.
Variables:
Clinical/Behavioral Variables of Interest:
Demographics (Education, Age, Gender, Ethnicity)
Subjective Memory Complaints (Patient and Informant)
APOE
MMSE total score
Logical Memory I and II raw and scaled scores
Category Fluency raw and scaled scores
Trails A & B raw scores and scaled scores
Boston Naming Test raw and scaled scores
GDS-15 total score
ADAS-Cog total score
CDR
FAQ item scores and total scores
Neuroimaging Variables of Interest:
MRI:
Hippocampal Volume
Entorhinal cortex Volume
Intracranial Volume
PET (FDG PET):
Parietal Flow
Temporal Flow
Global Flow |
| Additional Investigators |
Investigator's Name: |
Davangere P. Devanand |
E-mail: |
dpd3@columbia.edu
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Proposed Analysis: |
Objective 1: To identify the neuropsychological and neuroimaging correlates to functional impairment (FAQ) in individuals with Mild Cognitive Impairment, and to compare them to Alzheimer?s disease patients and controls.
Objective 2: To identify the individual FAQ items that distinguish the three diagnostic groups, and that are associated with the degree of neuropsychological deficits in tests of memory, verbal fluency, and executive function.
This project will be undertaken by Drs. Brown and Devanand continuing a line of research based on previous findings on the functional impairment of patients with MCI conducted in the Division of Geriatric Psychiatry at Columbia University (Tabert et al., Functional deficits in patients with mild cognitive impairment: Prediction of AD. Neurology 2002; 758-764), and relates to a new article in press by Landau et al. (2009) in Neurobiology of Aging.
Baseline evaluation data from the ADNI database only will be analyzed for this paper.
Variables:
Clinical/Behavioral Variables of Interest:
Demographics (Education, Age, Gender, Ethnicity)
Subjective Memory Complaints (Patient and Informant)
APOE
MMSE total score
Logical Memory I and II raw and scaled scores
Category Fluency raw and scaled scores
Trails A & B raw scores and scaled scores
Boston Naming Test raw and scaled scores
GDS-15 total score
ADAS-Cog total score
CDR
FAQ item scores and total scores
Neuroimaging Variables of Interest:
MRI:
Hippocampal Volume
Entorhinal cortex Volume
Intracranial Volume
PET (FDG PET):
Parietal Flow
Temporal Flow
Global Flow |
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