Barts and the London School of Medicine and Dentistry
Department:
Clinical Pharmacology
Country:
Proposed Analysis:
The objectives of my research study are to:
???Investigate the pharmacokinetic and pharmacodynamic (PK/PD) relationships of the acetylcholinesterase (AChE) inhibitors and other class of drugs used in the treatment of Alzheimer's disease and other dementia disorders.
???Perform a meta-analysis of the AChE inhibitors and construct a model that can be used as a 'reference' to predict the PK/PD profile of novel antidementia compounds in humans. To facilitate this research, I am interested in patient-level data to assess both inter-subject variability and mean response.
???Investigate the possible sources of pharmacokinetic or pharmacodynamic drug-drug interactions involving AChE inhibitors and other class of drugs used in the treatment of Alzheimer's disease and other dementia disorders.
???Investigate in silico models which may offer the possibility of simulating the pharmacodynamic effects of anti-dementia drugs in specific areas of the brain. This will be helpful in distinguishing purely symptomatic effects from disease-modifying effects, the latter being the ultimate goal of the modern pharmacology of dementia.
