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Techniques in NeuroImaging

CT (ROENTGEN -RAY COMPUTED TOMOGRAPHY)
A beam of x-rays passes through the brain and is detected according to the density of the tissue encountered. Detectors positioned around the circumference of the scanner collect attenuation readings from multiple angles. A computerized algorithm reconstructs an image of each slice.

MRI (MAGNETIC RESONANCE IMAGING)
When protons are placed in a magnetic field, they become capable of receiving and then transmitting electromagnetic energy. The strength of the transmitted energy is proportional to the number of protons in the tissue. Signal strength is modified by properties of each proton's microenvironment, such as its mobility and the local homogeneity of the magnetic field. MR signal can be "weighted" to accentuate some properties and not others.

When an additional magnetic field is superimposed, one which is carefully varied in strength at different points in space, each point in space has a unique radio frequency at which the signal is received and transmitted. This makes constructing an image possible. It represents the spatial encoding of frequency, just like a piano.

Read more about MRI physics >

SPECT/PET (SINGLE PHOTON/ POSITRON EMISSION COMPUTED TOMOGRAPHY)
When radiolabeled compounds are injected in tracer amounts, their photon emissions can be detected much like x-rays in CT. The images made represent the accumulation of the labeled compound. The compound may reflect, for example, blood flow, oxygen or glucose metabolism, or dopamine transporter concentration. Often these images are shown with a color scale.
SIMPLIFIED TABULATION OF TISSUE IMAGE CHARACTERISTICS:

NORMAL TISSUE:
MR-T1 MR-T2 Xray-CT2
Dense bone dark dark bright
Air dark dark dark
Fat bright bright dark
Water dark bright dark
Brain "anatomic"3 intermediate intermediate
1. Bright means high signal intensity, dark means low, and interm. means intermediate.
2. Bright means high density/high attenuation of x-rays, dark means low.
3. Grey matter appears grey, white matter white.

ABNORMAL TISSUE:
  MR-T1 MR-T2 Xray-CT2 Enhancement1
Infarct dark bright dark sub-acute
Bleed bright2 bright2 bright no
Tumor dark bright dark3 yes
MS plaque dark bright dark4 acute
1. Blood brain barrier leak. For MR, gadolinium; for CT, iodinated contrast material.
2. Unless very fresh or very old.
3. Unless calcified.
4. Often isodense.
 
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