LONI was originally
established to study cerebral metabolism with the goal of understanding
the relationship between brain structure and function using image
data. Work progressed into three-dimensional reconstruction and
visualization. This enabled the study of functional anatomy in
the same geometric configuration as that found in the living animal.
As these reconstructions became more sophisticated, their application
to computational atlases became possible.
The construction of brain atlases based on detailed representations
of anatomy in a standardized 3D coordinate system is the major
focus. The Laboratory addresses the problem of comparing data
across individuals as well as across modalities and increased
work in humans began. Work is focused on statistical manipulation
of the geometry that makes up the anatomic and functional data
sets as well as sophisticated visualizations permitting the communication
of the results.