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Grant Number: |
NIBIB P01 EB001955 |
Species: |
human
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Funding Dates: |
2003-07-04 - 2008-06-30 |
Grant URL: |
http://www.loni.ucla.edu/ICBM/ |
Grant Components: |
The Grant described here may have one or many components to it. Please use the links below for additional information about this Grant.
ICBM Grant Details
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ABSTRACT
Architecture - To establish the methodology and to obtain the datasets for macroscopic and microscopic brain structure and its cross-sectional study by age. Optimized post mortem protocols yield multiple sets of microstructural data from the same specimen. The interrelation among multiple histological methods defines architectonic data layers for each individual section in each specimen. Registering homologous layers of data from multiple subjects allows for the creation of multidimensional, histological, probabilistic maps. Population maps are analyzed in age groups at a minimum temporal resolution of one decade.
Functional Networks - The Function project encompasses analysis of data from normal human subjects using imaging modalities that are more intimately linked to the function of the brain than to traditional anatomy. These include functional MRI (fMRI) and positron emission tomography (PET) measures of blood flow, receptor binding densities as measured using PET, and brain connectivity patterns as assessed using transcranial magnetic stimulation and PET (TMS-PET).
Integrative Atlases - Imaging datasets collected in the Architecture and Function projects vary across time, scale, and in the structural and functional features assessed. This provides extraordinary potential to understand structure and function from a rich variety of perspectives, as they covary across subjects, and as they change dynamically in whole populations. The Integrative Atlases project is focused on the development of techniques to integrate data across time, spatial scale, and data modality. In addition, this integrative effort brings in genetic information as a first step in understanding the causes of the variance observed in the datasets.
Anatomy - To refine the anatomic framework of the probabilistic reference system upon which functional data will be mapped. The research provides in depth surveys of selected regions of the brain, always retaining the spatial localization of that survey to the whole. The focus is on the study of specific regions of the brain that correspond to expected activation sites in the functional studies.
Function ? To study functional landmarks and their use in augmenting atlasing methods that were based primarily on macroscopic structural anatomy.
Analysis - (1) To investigate various forms of automated 3D and 2D spatial normalization to establish the optimal approach for mapping functional neuroanatomy in different cortical and sub-cortical regions, (2) To unify the random field theories covering the statistical analysis of PET/fMRI/aMRI brain mapping data, extending it to detection of activation in non-Gaussian and non-stationary images, and (3) To improve the MRI and PET simulators for use in validation experiments. |
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