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ABSTRACT
The NLM grant has as an overall goal, the creation of an atlas of Alzheimer?s disease. The neuroscience and informatics efforts will result in a tool set and product that is applicable not only to the basic and clinical science of Alzheimer?s disease, but to the general problem of mapping the structure and function of any dynamic process in health or disease in whole populations of subjects. Leveraging the accomplishments achieved during the last period of this project and building upon our high-resolution post mortem anatomic framework, the development of atlas construction methodology and the ability to create 3D visual models of anatomy, we will construct the first multimodality probabilistic atlas of the brain representing a diseased population. Including both histologically processed post mortem tissue as well as high-resolution 3D MR images acquired from subjects in various stages of Alzheimer?s disease, we will generate the average geometry and 3D variability of the anatomic structures of these populations. Further, we will describe the anatomy as cytoarchitectural features from histology and gyral sulcal features from MRI. |
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