LONI: Laboratory of Neuro Imaging

Development

NORMAL DEVELOPMENT
Development studies seek to understand growth rates of different anatomical regions in normal and diseased individuals. By combining genetic data with anatomical imaging we are attempting to discover the critical time points of normal and abnormal maturation in the brain.

The Development Project maps anatomical changes associated with both normal and abnormal brain development. Using magnetic resonance images and sophisticated algorithms we are able to analyze the subtle changes in both shape and size of various regions that occur during childhood and adolescence.
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FETAL ALCHOHOL SYNDROME (FAS)

In 1973 Drs. Kenneth L. Jones and David W. Smith identified a specific pattern of malformations, growth deficiencies and Central Nervous System (CNS) dysfunctions that were observable in some offspring of alcoholic mothers. They termed this disorder Fetal Alcohol Syndrome(FAS).

At birth, children with FAS can be recognized by growth deficiency, a characteristic set of minor facial traits, and evidence of central nervous system dysfunction. They also show difficulties in learning,
memory, attention, problem solving, social interactions mental health. By far the most devastating effects are the effects of alcohol-induced damage to the developing brain. Because the effects of prenatal alcohol exposure on the developing brain appear to be long lasting and incapacitating, research has concentrated on brain malformations as well as cognitive and behavioral abnormalities.
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ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

Attention Deficit Hyperactivity Disorder (ADHD) was first described by William Still in 1902. It was later discovered that children who survived the viral encephalitis and meningitis outbreak in 1918
demonstrated symptoms of ADD. Over time, the terminology evolved from Still's original label of "morally defective" to "minimal brain damage" in the 1930's, and "minimal brain dysfunction" in the 1960's. Ultimately, it acquired the name we know today, ADHD.

ADHD is a diagnosis applied to children and adults who consistently display certain characteristic behaviors over a period of time.
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CHILDHOOD ONSET SCHIZOPHRENIA
Schizophrenia is a debilitating psychiatric disorder that affects 1% of adult Americans. Often striking without warning in the late teens or early twenties, its symptoms include visual and auditory hallucinations, psychotic outbreaks, bizarre or disordered thinking, as well as depression and social withdrawal. The childhood-onset form of the disorder is similar to the adult-onset form in many ways, but it is more severe.

Childhood onset schizophrenia affects about 1 child in 40,000, compared to 1 in 100 in adults. Children with schizophrenia experience difficulty in managing everyday life. They share with their adult
counterparts hallucinations, delusions, social withdrawal, flattened emotions, increased risk of suicide and loss of social and personal care skills. They may also share some symptoms with and be mistaken for children who suffer from autism or other pervasive developmental disabilities, which affect about 1 in 500 children. Children with schizophrenia tend to be harder to treat and have a worse prognosis than adult-onset schizophrenia patients.
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