http://www.loni.ucla.edu/Software/rss.php?package=REM Registration is a fundamental processing component of most biomedical image analysis methods. Registration when one image contains a region not in the other violates topological preservation, a constraint used in many modern registration methods. REM represents the source and target images as embedded maps that combine intensity and the imaging space into one geometric object, a manifold. Registration is the performed on the manifolds so that changes in image tolopology can be recovered as intensity transformations. The product is a combined geometric and intensity transformation matching the source and target images. Thu, 20 Jun 2013 02:58:18 +0000 5 0