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Mouse BIRN Projects
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Mouse BIRN
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Overview
Mouse BIRN (mBIRN) is a research and development effort funded by the National Center for Research Resources (NCRR) to produce an integrated framework for the collection, analysis, management, and visualization of diverse neuroscience data sets. It provides a test bed for the formulation of hardware, software, and protocols to produce a distributed adaptive database and multiscale, multimodality digital atlases of the mouse brain. These resrouces are used to share and mine multi-scale structural and functional data and integrate these with genomic and gene expression data. The goal is to create an infrastructure that can greatly enhance previously disparate data collections into a single system capable of quantitative visualization and linkage with previously disconnected knowledge bases.
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Individual projects
- MouseBIRN Individual Projects
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More information about some of the current mouse BIRN projects
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| META FILEATTACHMENT | overview.pdf | attr="" comment="OVERVIEW OF THE BIRN PROJECT" date="1115770796" path="C:\Documents and Settings\jboline\Desktop\overview.pdf" size="267570" user="MiraeYang" version="1.1" |
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Mouse BIRN Projects
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Overview
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<
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Mouse BIRN (mBIRN) is a research and development effort to produce integrated frameworks for the collection, analysis, management, and visualization of neuroscientific data. It provides a test bed for the formulation of hardware, software, and protocols to effectively produce a distributed adaptive database and multiscale, multimodality digital mouse brain atlases. These are used to share and mine multi-scale structural and functional data and integrate these with genomic and gene expression data. The goal is to create an infrastructure for the mouse brain that can greatly enhance previously disparate data collections into a single system capable of quantitative visualization and linkage with previously disconnected knowledge bases.
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>
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Mouse BIRN (mBIRN) is a research and development effort funded by the National Center for Research Resources (NCRR) to produce an integrated framework for the collection, analysis, management, and visualization of diverse neuroscience data sets. It provides a test bed for the formulation of hardware, software, and protocols to produce a distributed adaptive database and multiscale, multimodality digital atlases of the mouse brain. These resrouces are used to share and mine multi-scale structural and functional data and integrate these with genomic and gene expression data. The goal is to create an infrastructure that can greatly enhance previously disparate data collections into a single system capable of quantitative visualization and linkage with previously disconnected knowledge bases.
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Significance
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mBIRN is acquiring complete volumetric coverage with MR, cryosections, conventional histology, and gene expression from the same specimen along with confocal light microscopy, and electron tomography from closely related specimens. This allows the neuroscientists studying the mouse models the ability to view the complex anatomy of the mouse brain in 3 dimensions at multiple scales for tissue and structure differentiation, along any arbitrary plane, and all from a single computer screen.
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mBIRN is acquiring complete volumetric coverage with magnetic resonance imaging (MR), cryosections, conventional histology, and gene expression from common specimens along with confocal light microscopy, and electron tomography from closely related specimens. This allows the neuroscientists studying the mouse models the ability to view the complex anatomy of the mouse brain in 3 dimensions at multiple scales for tissue and structure differentiation, along any arbitrary plane, and all from a single computer screen.
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Combing these techniques with well characterized mouse models, it becomes much easier to understand the disease mechanism and potential therapies. The development of MR microscopy in mouse models makes transition of imaging studies possible from mouse to human. mBIRN will complete the link making correlation possible between fundamental structural units (e.g., the dendritic spine), gene expression, traditional histology, magnetic resonance histology, and in vivo MR imaging. The products of mBIRN, including the initial data sets for these models, the tools for comparison, the infrastructure for sharing the data and the knowledge base, will all clearly be extensible to a much broader community as scientists seek to connect an exponentially increasing number of mouse models to human disease.
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Combining these techniques with well characterized mouse models, it becomes much easier to understand the disease mechanism and potential therapies. The development of MR microscopy in mouse models makes transition of imaging studies possible from mouse to human. mBIRN will complete the link making correlation possible between fundamental structural units (e.g., the dendritic spine), gene expression, traditional histology, magnetic resonance histology, and in vivo MR imaging. The products of mBIRN, including the initial data sets for these models, the tools for comparison, the infrastructure for sharing the data and the knowledge base, will all clearly be extensible to a much broader community as scientists seek to connect an exponentially increasing number of mouse models to human disease.
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Mouse BIRN Projects
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Combing these techniques with well characterized mouse models, it becomes much easier to understand the disease mechanism and potential therapies. The development of MR microscopy in mouse models makes transition of imaging studies possible from mouse to human. mBIRN will complete the link making correlation possible between fundamental structural units (e.g., the dendritic spine), gene expression, traditional histology, magnetic resonance histology, and in vivo MR imaging. The products of mBIRN, including the initial data sets for these models, the tools for comparison, the infrastructure for sharing the data and the knowledge base, will all clearly be extensible to a much broader community as scientists seek to connect an exponentially increasing number of mouse models to human disease.
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Partner Institutions
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mBIRN integrates the activities of five existing laboratories:
- The MRI Center in the Biological Imaging Center (BIC) at the California Institute of Technology (CIT)
- The Center for In Vivo Microscopy (CIVM) at Duke University
- The Laboratory of Neuro Imaging (LONI) at the University of California at Los Angeles (UCLA)
- The National Center for Microscopy and Imaging Research (NCMIR) at the University of California at San Diego (UCSD)
- The Informatics Center for Mouse Neurogenetics at the University of Tennessee Health Sciences Center (UTHSC)
These laboratories will be connected by the networking and software infrastructure that is being co-developed with the BIRN Central Coordinating site (BIRN-CC).
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| META FILEATTACHMENT | overview.pdf | attr="" comment="OVERVIEW OF THE BIRN PROJECT" date="1115770796" path="C:\Documents and Settings\jboline\Desktop\overview.pdf" size="267570" user="MiraeYang" version="1.1" |
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Mouse BIRN Projects
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>
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Mouse BIRN
Overview
Mouse BIRN (mBIRN) is a research and development effort to produce integrated frameworks for the collection, analysis, management, and visualization of neuroscientific data. It provides a test bed for the formulation of hardware, software, and protocols to effectively produce a distributed adaptive database and multiscale, multimodality digital mouse brain atlases. These are used to share and mine multi-scale structural and functional data and integrate these with genomic and gene expression data. The goal is to create an infrastructure for the mouse brain that can greatly enhance previously disparate data collections into a single system capable of quantitative visualization and linkage with previously disconnected knowledge bases.
Significance
mBIRN is acquiring complete volumetric coverage with MR, cryosections, conventional histology, and gene expression from the same specimen along with confocal light microscopy, and electron tomography from closely related specimens. This allows the neuroscientists studying the mouse models the ability to view the complex anatomy of the mouse brain in 3 dimensions at multiple scales for tissue and structure differentiation, along any arbitrary plane, and all from a single computer screen.
Combing these techniques with well characterized mouse models, it becomes much easier to understand the disease mechanism and potential therapies. The development of MR microscopy in mouse models makes transition of imaging studies possible from mouse to human. mBIRN will complete the link making correlation possible between fundamental structural units (e.g., the dendritic spine), gene expression, traditional histology, magnetic resonance histology, and in vivo MR imaging. The products of mBIRN, including the initial data sets for these models, the tools for comparison, the infrastructure for sharing the data and the knowledge base, will all clearly be extensible to a much broader community as scientists seek to connect an exponentially increasing number of mouse models to human disease.
Partner Institutions
mBIRN integrates the activities of five existing laboratories:
- The MRI Center in the Biological Imaging Center (BIC) at the California Institute of Technology (CIT)
- The Center for In Vivo Microscopy (CIVM) at Duke University
- The Laboratory of Neuro Imaging (LONI) at the University of California at Los Angeles (UCLA)
- The National Center for Microscopy and Imaging Research (NCMIR) at the University of California at San Diego (UCSD)
- The Informatics Center for Mouse Neurogenetics at the University of Tennessee Health Sciences Center (UTHSC)
These laboratories will be connected by the networking and software infrastructure that is being co-developed with the BIRN Central Coordinating site (BIRN-CC).
| META FILEATTACHMENT | overview.pdf | attr="" comment="OVERVIEW OF THE BIRN PROJECT" date="1115770796" path="C:\Documents and Settings\jboline\Desktop\overview.pdf" size="267570" user="MiraeYang" version="1.1" |
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