ADNIClinicalFAQ < ADNI

---++ <font color=#0c460c>Clinical Data FAQ</font>

*Q1:  How do I get the clinical data?*

A1:  The clinical data set may be downloaded from LONI [[http://www.loni.ucla.edu/ADNI/Data/ADCS_Download.jsp][here]] (authorized users only).

The ADNI Biostatistics Core at UC Davis has provided a [[http://www.loni.ucla.edu/twiki/pub/ADNI/ADNIClinicalFAQ/ADNItraininghandout.pdf][tutorial]] on downloading and importing the data into SAS, Stata, and R.

*Q2:  How is missing data coded in the datasets?*

A2:  Missing data is coded with -1 and -4. Generally, -4 is used for "passively" missing or not applicable (e.g. item is not collected at a particular visit), and -1 is used for data which is confirmed missing at point of data entry.

*Q3:  Which column in all the CSV files is the ADNI subject ID number correspondent to the "Subject ID" number in the LONI-ADNI database, the "ID" column or the "RID" column?*

A3:  In the ADNI subject IDs of the form 123_S_5678, the last 4 digits correspond to the roster ID (RID) which you see in every CSV file. You can also refer to the adni_roster table which lists RIDs and their associated PTIDs (of the form 123_S_5678).

*Q4:  Where can I find a copy of the cognitive assessment worksheets (ADAS-Cog, etc.) used to score patients at each visit?*

A4:  There are three versions of the ADNI cognitive assessments ([[http://www.loni.ucla.edu/twiki/pub/ADNI/ADNIClinicalFAQ/BLCogTestingWorksheet.pdf][baseline]], 
[[http://www.loni.ucla.edu/twiki/pub/ADNI/ADNIClinicalFAQ/M6CogTestingWorksheets.pdf][month 6]],
[[http://www.loni.ucla.edu/twiki/pub/ADNI/ADNIClinicalFAQ/M12CogTestingWorksheets.pdf][month 12]]). Refer to Cognitive Assessment section of the [[http://www.loni.ucla.edu/twiki/pub/ADNI/ADNIClinicalFAQ/adniproceduresmanual12.pdf][Procedures Manual]] for information regarding cognitive assessments at visits other than BL, M6 and M12.

*Q5:  Where can I find ADAS-Cog total scores?*

A5: Item level scores and two versions of total scores are available in the adni_adasscores file. TOTAL11 corresponds to the total score on the 11-item ADAS (items 4 and 13 omitted) and TOTALMOD corresponds to the total score on the modified 13-item ADAS (item 13 omitted). 

|||  *ADAS-Cog*  ||  *Modified  ADAS-Cog*  |
|||  (TOTAL11)  ||  (TOTALMOD)  |
|||[[http://www.ncbi.nlm.nih.gov/pubmed/6496779][Rosen  et  al.,  1984]]  (modified  Mohs,  1994)*||[[http://content.nejm.org/cgi/content/abstract/NEJMoa050151][Petersen  et  al.,  2005]]|
|1|Word  Recall|    10    ||  10  |
|2|Commands|  5  ||  5  |
|3|Construction|  5  ||  5  |
|4|Delayed  Word  Recall|  --  ||  10  |
|5|Naming|  5  ||  5  |
|6|Ideational  Praxis|  5  ||  5  |
|7|Orientation|  8  ||  8  |
|8|Word  Recognition|  12  ||  12  |
|9|Recall  Instructions|  5  ||  5  |
|10|Spoken  Language|  5  ||  5  |
|11|Word  Finding|  5  ||  5  |
|12|Comprehension|  5  ||  5  |
|14|Number  Cancellation|  --  ||  5  |
||*Total*|  *70*  ||  *85*  |

* unpublished manual


Raw item level responses are available in the adni_adas file.

*Q6:  What is the meaning of the visit identifier "Not Yet Determined" (NV)?*

A6: The NV ("No Visit" or "Not Yet Determined") visit code is applied when
we receive scan QC data (e.g. mrinclusio) before we receive scan
information sheets (e.g. mrimeta). In these instances, we do not yet
know with which visit the scan QC data is associated.

Occasionally scan QC and scan information records which should be linked
are not linkable because of discrepant data (e.g. exam dates do not
match). The NV data code will be used in these cases as well, until the
discrepancies are corrected.

*Files:*

   * [[%ATTACHURL%/adniproceduresmanual12.pdf][adniproceduresmanual12.pdf]]: ADNI Procedures Manual

   * [[%ATTACHURL%/BLCogTestingWorksheet.pdf][BLCogTestingWorksheet.pdf]]: BL Cog Testing Worksheet

   * [[%ATTACHURL%/M6CogTestingWorksheets.pdf][M6CogTestingWorksheets.pdf]]: M6 Cog Testing Worksheets

   * [[%ATTACHURL%/M12CogTestingWorksheets.pdf][M12CogTestingWorksheets.pdf]]: M12 Cog Testing Worksheets

---++++++ Topic permissions

   * Set ALLOWTOPICCHANGE = Main.AdniGroup

   * [[%ATTACHURL%/CommitteeConfirmedConversionsasof30Jan2009.pdf][CommitteeConfirmedConversionsasof30Jan2009.pdf]]: Confirmed Conversions
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