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CCB Collaborators Visit: January 31 - February 01, 2008.

Logistics

Project Title: The Cardiac Atlas Project (CAP)

  • Abstract:
    The goal of this project is to establish a web accessible structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. Inaugurated with a substantial number of cardiac magnetic resonance (CMR) examinations, together with derived functional analyses and associated clinical information, the Cardiac Atlas Project (CAP) database will be extendible to allow inclusion of data from coronary angiography, ECG, histology, blood proteins, peptides and other serological data, and genomic information in the longer term. An initial goal of the project is to facilitate statistical analysis across population groups of regional heart shape and wall motion characteristics, via the application of parametric mathematical modeling tools. The parametric modeling tools and associated ontological schema will also facilitate data fusion between different imaging protocols and modalities as well as other data sources. The CAP will be developed in collaboration with the Center for Computational Biology (CCB) at UCLA [1], and will exploit and extend the brain mapping infrastructure developed by the CCB. The Cardiac Atlas Project will advance the aims of the National Centers for Biological Computing (NCBC) collaboration program by extending the computational atlases of the Center for Computational Biology to another organ: the heart.

Itinerary

Thursday (01/31/08)

Friday (02/01/08)

General Project Challenges

  • IRB Approval
  • Upload of ~15,000 cases to establish the database
  • Definition of a standard cardiac coordinate system
  • Definition of a cardiac radiological ontology

Computational and Statistical Challenges

  • Development of open source modeling tools for cardiac shape and motion
  • Parametric mapping between study analyses.
  • Statistical tools for quantifying abnormalities in regional wall motion

Materials