CCB Roadmap (2007) Unsolved Problems

Implement value, vector and tensor uni/multivariate statistics for population studies

Overview

• This project aims at developing stand-alone tools for statistical analysis of group differences using displacement (warping) fields, based on the mathematical models and Matlab implementations developed by Paul Thompson and Natasha Lepore.

Requirements

• Univariate measures (Mostly exist - see Pipeline, T-tests and ANOVAs)
• Vector-valued stat maps:
  • This tool should be invoked via AIR-like command-line syntax
    • stat_maps -nog number_of_groups NumSubjGrp1^? ... NumSubjGrp^? -grp1 Grp1Fld1.fld ... Grp1Fld_k1.fld [-grp2 Grp2Fld1.fld ... Grp2Fld_k2.fld] -output outputFileName [options]
  • Stat maps should include (Hotelling's T2, log(J^TJ), and variaties of the maps reported in the pubs below)
  • The Pipeline and Grid binaries for the prototype version of the tool are available (via the Pipeline environment and CCB SVN (Natasha's Matlab code)).
  • A tested Fortran version of the multvariate Hotelling's T2 statistics is built and available on the Grid (cerebro-rcc.loni.ucla.edu) at: /cxfs/ccb/CCB_SW_Tools/others/Statistics/HotellingT2Statistics, and available via the Pipeline.
• Extended stat maps to DTI tensors (talk to NathanHageman, PaulThompson, Ming-Chang Chiang)?

Status

• Version 0.9 delivered and and available through the pipeline, integrated with KL_MI registration (full testing cycle required).

Pipeline Usage Documentation

• Complete Documentation available here
• Latest version of TBM Pipeline (01/08/08)

References

• Lepore_Brun_Thompson_2006.pdf
• Joshi_Shattuck_Thompson2006.pdf
• MingChangChiang_WilliamsSyndrome_THompson_2007.pdf
• YiYuChou_Lepore_Thompson2007.pdf