CurrentMouseStrains < MouseBIRN

Preferred terms for Mouse Strains in BIRNLex

BALB/cJ
- Bonfire_ID: C1516114
- Jax Stock ID: 000651
- BIRN_definition: A substrain of BALB/c mouse developed at Jackson Laboratory. From Jackson: nbr 150 +?.Snell to Jackson Laboratory after 1940. Males of this substrain are extremely aggressive and will fight if housed together once mature. The Lac substrain separated in 1952 is non-aggressive. Maintained by J, Ola (JLac substrain). (http://www.informatics.jax.org/external/festing/mouse/docs/BALB.shtml)

C57BL/6J
- Bonfire_ID BF_T0000259
- Jax Stock ID: 000664
- BIRN_definition: The C57BL/6 substrain of laboratory mouse bred by the Jackson Laboratory. From Jackson: Inbr (J) 150. Origin: substrains 6 and 10 were separated prior to 1937. This substrain is now probably the most widely used of all inbred strains. Substrain 6 and 10 differ at the H9, Igh2 and Lv loci. Maint. by J,N, Ola. \par (http://www.informatics.jax.org/external/festing/mouse/docs/C57BL.shtml)

CBA/J
- Bonfire_ID: C1511406
- Jax Stock ID: 000656
- BIRN_definition: A substrain of CBA mouse developed at the Jackson Labs. The following information was provided by Jackson Labs; Strong, to Andervont 1947, to Jackson Laboratory 1948. Carries gene for retinal degeneration (rd). Skin grafts between CBA/J and CBA/Ca are rejected (Green and Kaufer, 1965). http://www.informatics.jax.org/external/festing/mouse/docs/CBA.shtml

C3HeB/FeJ
- Bonfire_ID: C1511368
- Jax Stock ID: 000658
- BIRN_definition: A substrain of the CH3 laboratory mouse. From Jackson Laboratories: This strain does not carry mouse mammary tumor virus (MMTV). See JAX Notes, May 2000, #480. This strain is also homozygous for the retinal degeneration allele Pde6brd1. (see also http://www.informatics.jax.org/external/festing/mouse/docs/C3H.shtml

FVB/NJ
- Bonfire_ID: BF_T0000377
- Jax Stock ID: 001800
- BIRN_definition: A substrain of the FVB inbred laboratory mouse. From Jackson Laboratories: FVB/NJ was inbred for the fv1b allele which confers sensitivity to the Friend leukaemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. Relative to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE^?. Despite having the H2q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis...Strain development: In 1966, outbred Swiss mice at the National Institues of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1b allele which confers sensitivity to the Friend leukaemia virus B strain. The FVB/N strain resulted from inbreeding this line for the fv1b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87. (see also http://jaxmice.jax.org/strain/001800.html).

B6;129-/Slc6a3^tm2Mca
- Bonfire_ID: BF_T0000376
- MGI_ID:
- BIRN_definition: Genetically modified mouse in which the dopamine transporter was knocked out by targeted mutation. The mouse was produced in the laboratory of Dr. Marc Caron, Duke University. (Giros B, et al., Nature. 1996 379(6566):606-12.)

B6;D2-Tg(PDGFB-SNCA)NNEma
- Bonfire_ID: BF_T0000378
- MGI_ID: MGI:1353749
- BIRN_definition: Genetically modified mouse in which the transgene for human alpha synuclein is expressed under the control of the platelet derived growth factor promotor. The mouse was produced in the laboratory of Dr. Eliezer Masliah (Masliah et al., Science. 2000 Feb 18;287(5456):1265-9). NN is the line number; for the D line, B6;D2-Tg(PDGFB-SNCA)4Ema