Overview
The mouse BIRN EAE mouse model of Multiple Sclerosis is a collaborative project spearheaded by Allan
MacKenzie-Graham at LONI at UCLA.
Goals
Goals here
Planning
Plans and Action Items
Working Pages
- Links to related working pages
Minutes, etc.
Other important information and links
- Links to areas of interest to the topic
Updates/Progress
- July-August 2005: High resolution MRI scans of EAE and normal controls initiated at DUKE
- July-August 2005: Processing of these high resolution scans initiated at UCLA
- April 2005-2006:
- 32 T2 images were processed, registered into a common space to create a minimum deformation atlas. This atlas was used to look for anatomical differences between normal and EAE animals. Significant differences were found in the cerebellar volumes of control and EAE animals. A manuscript describing the results of this collaboration between BIC and LONI is in preparation for Neuroimage.
- 24 animals were scanned with high resolution active stain MRM at CIVM. These scans have been processed in the same manner as above at LONI. Tools and pipelines for analyzing these high resolution data were set in place for use by other members of mouse BIRN.
- 12 DTI scans from a Shiverer study at BIC were analyzed in the same manner. No differences were found in the cerebellar volumes of the Shiverer mice and the control animals.
- Oct 2005: Tools and pipelines along with tutorial for processing high resolution MRI data shared with the group at here.
- May 2006: Publication accepted
- EAE_workplan_May06.doc: 05/06: Updated progress and work plan document
EAE_workplan_6_1_05.doc 
EAE_workplan_6_1_05.pdf