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Plaque
Clearance, Antibody Isotype Are Key for Passive Ab Immunization
6 February 2003.
Plaque clearance is a better correlate of neural protection
via passive amyloid immunization than soluble amyloid-beta
(Ab) clearance, and this protection
is based on Fc receptor-mediated Ab
phagocytosis... |
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Ab's Shadowy Sibling—What Becomes of the
Intracellular Domain?
4 February 2003. In the January
31 online PNAS, Meir Scheinfeld, Shuji Matsuda, and Luciano
D'Adamio of the Albert Einstein College of Medicine in Bronx,
New York, show how the carboxyl terminus of AbPP could play a significant role in gene
transcription... |
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Nathan
Kline Institute in Peril
4 February 2003. Faced with a
multibillion dollar deficit, New York State’s Governor George
Pataki last week proposed a budget plan that would merge the
Nathan Kline Institute for Psychiatric Research in Orangeburg
with the New York State Psychiatric Institute in
Manhattan... |
GO TO ALL RESEARCH
NEWS  |
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In the spotlight
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Alzheimer's Destruction
Live
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View these animated 3-D
video maps to see how Alzheimer's disease spreads through the
living brain. Paul Thompson and colleagues at UCLA, with
collaborators in Australia and England, used MRI volumetry to
assess tissue loss in 14 AD patients and 14 controls every
three months for two years. These brain maps show the dynamic
wave of gray matter loss that occurs as patients progress from
mild to severe Alzheimer's disease. Blue colors indicate brain
regions with no detectable tissue loss, red colors denote
regions with up to 10% tissue loss, and white areas up to 20%
loss. [Image from Thompson P et al., Dynamics of Gray Matter
Loss in Alzheimer's Disease, J.Neuroscie, 1 February 2003].
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Live
Discussion Background Text by Stephen Greenberg and Mathias
Jucker |
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Amyloid stuck in the
brain's blood vessels: does it hasten the symptoms of
Alzheimers', choke circulation to bring on strokes, or perhaps
do nothing much? To satisfy your curiosity about cerebral
amyloid angiopathy, join Stephen Greenberg and Mathias Jucker
on March 12, noon EST, for a live discussion. |
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AD
Experiences |
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In "Chronicle of a
Caregiver," Sarah Goodwin write about her personal experience
as a wife caring for a husband who struggles with Alzheimer's.
She hopes her honest account of the daily frustrations, anger,
despair and occasional joys will let others know they are not
alone. She shares the insights and strategies that helped her
get through each day. We will be publishing her story in
weekly installments. We welcome your comments. |
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Enabling
Technologies |
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Step back from
day-to-day routine and take a break to ponder the big scheme
of things in Alzheimer’s research. Which knowledge gaps slow
down progress the most? Which technologies have matured
sufficiently to fill those gaps? Share the thoughts of a
diverse group of scientists who met last year to discuss these
questions, and take away inspiration and ideas for your own
work. |
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Important
News on Mouse Models |
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The Jackson Laboratory
has appointed a special research administrator for Alzheimer's
disease (AD) to enhance the distribution of mouse models
important to AD research. Dr. Carol Linder will serve as a
resource for scientists seeking information about existing
models, and also oversee the importation, rederivation, and
distribution of new AD models. For information on AD-relevant
strains, visit the Neurobiology Research Models page. Scientists
with questions or information about potential new strains for
distribution can reach Dr. Linder by e-mail (ccl@jax.org) or phone
(207)-288-6230.
Jackson is currently developing a distribution colony of
David Borchelt's co-injected APPswe/PSEN1(deltaE9) strain.
Those interested in this model are urged to place an advance
order so that an appropriate number of animals can be bred for
the distribution colony. Contact Customer Service
(800-422-MICE or orderquest@jax.org) or register
online
Strain Name: B6C3-Tg(APP695)85Dbo Tg(PSEN1)85Dbo
Stock Number: 004462
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Haven't
paid much attention to apoE lately? |
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It's still the most
solid risk factor for the majority of Alzheimer's cases. Yet
how it does its damage is still a brainteaser. Refresh your
knowledge by reading this apoE news
update, and write in with corrections, amendments, missing
links, or opinions. |
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Announcing
the Gottlieb/ISOA Drug Discovery Award for Alzheimer's
Disease |
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A major new award for
research into Alzheimer's disease has just been announced.
Sponsored by Anne and Howard Gottlieb, and the Institute for
the Study of Aging (ISOA), the Gottlieb/ISOA Drug Discovery
Award will be presented to a scientist who has made a
significant contribution that leads to drug discovery or
clinical development for Alzheimer's disease. The award is
accompanied by a substantial prize of $100,000 to be used
toward Alzheimer's research.
Scientists or clinicians working in an academic institution
or a small biotechnology company are eligible. The winner,
selected by a jury of preeminent scientists, will be announced
in the fall of 2003. Nomination forms, which are available
online at ISOA (http://www.aging-institute.org/), must be
submitted before May 1, 2003. |
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What's New
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Comment
by Gunnar Gouras on Mutant AbPP Retards Growth in Hippocampus
before Plaques Form - 10 February 2003
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New
Resources in Patient Care - 10 February 2003
New
Resources:
The HD Lighthouse, a voluntary effort to serve
the Huntington Disease Community. The site provides
information on diagnosis, treatment and care, research, and a
community forum.
HOPES: Huntington's Outreach Project for
Education, at Stanford. A public web resource on Huntington's
Disease developed by a team of students and faculty at
Stanford University . The site focuses on the scientific
information on HD, including HD basics, causes of HD,
diagnosis, treatments, and related science. |
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Conference
Calendar - 10 February 2003
19-23 March 2003.
87th International Titisee Conference. Schwarzwald-Hotel
Titisee, Heidesheim, Germany. |
SEE
MORE | |
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